Tetramer formation of p53 is essential for its tumor suppressor function. p53 not only acts as
a tumor suppressor protein by inducing cell cycle arrest and apoptosis in response to …

Chemical topology has emerged as one intriguing feature in protein engineering. Nature
demonstrates the elegance and power of protein topology engineering in the unique …

Nuclear pore complexes (NPCs) form a selective filter that allows the rapid passage of
transport factors (TFs) and their cargoes across the nuclear envelope, while blocking the …

Mutations in the oligomerization domain of p53 are genetically linked to cancer susceptibility
in Li-Fraumeni Syndrome. These mutations typically alter the oligomeric state of p53 and …

Entangled proteins have attracted significant research interest. Herein, we report the first
rationally designed lasso proteins, or protein [1] rotaxanes, by using a p53dim‐entwined …

Lysosomal associated membrane protein 3 (LAMP3) is a newly identified tumor-specific
protein. It is a downstream target gene of tumor suppressor TP53 and its expression has …

The tumor suppressor p53, a 393-amino acid transcription factor, induces cell cycle arrest
and apoptosis in response to genotoxic stress. Its inactivation via the mutation of its gene is …

Acetylation of multiple lysine residues in the p53 plays critical roles in the protein stability
and transcriptional activity of p53. To better understand how p53 acetylation is regulated, we …

Herein, we report the biosynthesis of protein heterocatenanes using a programmed
sequence of multiple post‐translational processing events including intramolecular chain …

The tumor suppressor p53 presents a great challenge for 3D structural analysis due to its
inherent flexibility. In this work, we gained insight into the structure of full‐length wild‐type …