Because of its high prevalence and poor long-term clinical treatment effect, liver disease is
regarded as a major public health problem around the world. Among them, viral hepatitis …

Tanshinone IIA, a major bioactive constituent of Danshen, a Chinese herbal medicine, has
gained extensive exploration owing to its unique structural features and multiple promising …

Enzymatic hydrolysis has been validated as an appropriate strategy for improving the
properties of natural protein. Here, we used enzymatic hydrolysis sodium caseinate (Eh …

Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) and tryptophan 2, 3-dioxygenase (TDO),
catalyzing the first and rate-limiting step of tryptophan-kynurenine (Trp-Kyn) metabolism …

Although bioactive compounds (BCs) have many important functions, their applications are
greatly limited due to their own defects. The development of nanocarriers (NCs) technology …

Tanshinones are an important type of natural products isolated from Salvia miltiorrhiza
Bunge with various bioactivities. Tanshinone IIa, cryptotanshinone and tanshinone I are …

We report the structural optimization of tanshinone IIA, a natural product which possesses
anti-tumor properties but low water-solubility, weak antiproliferative activity and poor PK …

The interaction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-
binding domain (RBD) of spike protein with angiotensin-converting enzyme 2 (ACE2) …

In the traditional fermented food processes, inoculating the solid or semi-solid cultures of the
last batch to the fresh matrix (Huizao) for initiating the fermentation or regulating the niches …

Drug resistance represents a major obstacle to improving the overall response and survival
of cancer patients. Taxol is one of the most commonly used chemotherapy agents in breast …