In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …

Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool to investigate the
structure and dynamics of RNA, because many biologically important RNAs have …

Solution NMR spectroscopy represents a powerful tool for examining the structure and
function of biological macromolecules. The advent of multidimensional (2D-4D) NMR …

Combined IR and UV laser spectroscopic techniques in molecular beams merged with
theoretical approaches have proven to be an ideal tool to elucidate intrinsic structural …

The known biological functions of RNA have expanded in recent years and now include
gene regulation, maintenance of sub-cellular structure, and catalysis, in addition to …

RNA or single-stranded DNA aptamers with 2′-F pyrimidines have been pursued to
increase resistance to nucleases, and while it seems likely that these and other …

Functional nucleic acids (FNAs) tailoring has recently gained traction as a strategic
application in nanobiosensor design and drug delivery, yet the principle and methods of …

Structural information on RNA, emerging more and more as a major regulator in gene
expression, dramatically lags behind compared with information on proteins. Although NMR …

The well-known correlation between structure and functionality has motivated generations of
scientists to intensively investigate the structural behaviour of peptide and protein systems …