G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy
E Ruggiero, SN Richter - Nucleic acids research, 2018 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …
[HTML][HTML] The restriction factors of human immunodeficiency virus
RS Harris, JF Hultquist, DT Evans - Journal of Biological Chemistry, 2012 - ASBMB
Cellular proteins called" restriction factors" can serve as powerful blockades to HIV
replication, but the virus possesses elaborate strategies to circumvent these barriers. First …
replication, but the virus possesses elaborate strategies to circumvent these barriers. First …
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef
Y Usami, Y Wu, HG Göttlinger - Nature, 2015 - nature.com
HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly
enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent …
enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent …
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
A retroviral vector system based on the human immunodeficiency virus (HIV) was developed
that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous …
that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous …
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human
gene therapy because they mediate the in vivo delivery and long-term expression of …
gene therapy because they mediate the in vivo delivery and long-term expression of …
HIV-1 pathogenesis
M Stevenson - Nature medicine, 2003 - nature.com
Despite considerable advances in HIV science in the past 20 years, the reason why HIV-1
infection is pathogenic is still debated and the goal of eradicating HIV-1 infection remains …
infection is pathogenic is still debated and the goal of eradicating HIV-1 infection remains …
[HTML][HTML] Protein N-myristoylation: functions and mechanisms in control of innate immunity
Protein N-myristoylation is an important fatty acylation catalyzed by N-myristoyltransferases
(NMTs), which are ubiquitous enzymes in eukaryotes. Specifically, attachment of a myristoyl …
(NMTs), which are ubiquitous enzymes in eukaryotes. Specifically, attachment of a myristoyl …
Lentiviruses as gene transfer agents for delivery to non-dividing cells
L Naldini - Current opinion in biotechnology, 1998 - Elsevier
Lentiviral vectors are proving to be effective agents for the direct delivery and sustained
expression of a transgene in several tissues, including brain, retina, muscle and liver …
expression of a transgene in several tissues, including brain, retina, muscle and liver …
Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene
MY Chowers, CA Spina, TJ Kwoh, NJ Fitch… - Journal of …, 1994 - Am Soc Microbiol
The replication competence of human immunodeficiency virus type 1 genomes containing
mutations in the nef open reading frame was evaluated in continuous cell lines. Mutants that …
mutations in the nef open reading frame was evaluated in continuous cell lines. Mutants that …
Proline‐rich (PxxP) motifs in HIV‐1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down …
Human immunodeficiency virus (HIV) and simian immunodeficiency virus Nef proteins
contain a conserved motif with the minimal consensus (PxxP) site for Src homology region 3 …
contain a conserved motif with the minimal consensus (PxxP) site for Src homology region 3 …