Central nervous system (CNS) neurodegenerative diseases are characterized by faulty
intracellular transport, cognition, and aggregate regulation. Traditionally, neuroprotection …

Modification of the histone proteins associated with DNA is an important process in the
epigenetic regulation of DNA structure and function. There are several known modifications …

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease characterized
with autoimmune response against myelin proteins and progressive axonal loss. The …

Large-scale comparisons of patients and healthy controls have unearthed genetic risk
factors associated with a range of neurological and psychiatric illnesses. Meanwhile, brain …

Alzheimer's disease (AD) is the most common type of dementia in the elderly. It is
characterized by the deposition of two forms of aggregates within the brain, the amyloid β …

Genome-wide association studies have revealed several genes predisposing to
autoimmunity, however, concordance rates in monozygotic twins are significantly below …

Little information is available regarding mechanistic links between epigenetic modifications
and autoimmune diseases. It seems plausible to surmise that aberrant gene expression and …

Epigenetics is defined as the study of all inheritable and potentially reversible changes in
genome function that do not alter the nucleotide sequence within the DNA. Epigenetic …

The application of structural and functional magnetic resonance imaging (MRI) techniques in
patients with multiple sclerosis (MS) has certainly helped to improve our understanding of …

Major depressive disorder (MDD) represents approximately 40% of the disability caused by
mental illnesses globally. The poorly understood pathophysiology and limited efficiency of …