Abstract Perturbed Endoplasmic Reticulum (ER) calcium (Ca 2+) homeostasis emerges as a
central player in Alzheimer disease (AD). Accordingly, different studies have reported …

The current state of the AD research field is highly dynamic is some respects, while
seemingly stagnant in others. Regarding the former, our current lack of understanding of …

The role of skeletal muscle in nonshivering thermogenesis (NST) is not well understood.
Here we show that sarcolipin (Sln), a newly identified regulator of the sarco/endoplasmic …

INTRODUCTION Ryanodine receptors (RyRs) are intracellular Ca2+ channels that control
the release of Ca2+ from the sarco (endo) plasmic reticulum. Among the three mammalian …

Coordinated release of calcium (Ca2+) from the sarcoplasmic reticulum (SR) through
cardiac ryanodine receptor (RYR2) channels is essential for cardiomyocyte function. In …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant
inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine …

Pigs lack functional uncoupling protein 1 (UCP1) making them susceptible to cold.
Nevertheless, several pig breeds are known to be cold resistant. The molecular mechanism …

Cardiovascular diseases, such as stroke and myocardial infarction (MI) remain the major
cause of death and disability worldwide. However, the mortality of MI has declined …

Mutation T4825I in the type 1 ryanodine receptor (RYR1 T4825I/+) confers human malignant
hyperthermia susceptibility (MHS). We report a knock-in mouse line that expresses the …

In heart failure (HF), arrhythmogenic Ca2+ release and chronic Ca2+ depletion of the
sarcoplasmic reticulum (SR) arise due to altered function of the ryanodine receptor (RyR) …