New hope for the treatment of type 1 diabetes has recently emerged from the encouraging
results of islet cell transplantation in humans during the last few years. Although still facing …

Background. Experimental and clinical evidence has demonstrated that the establishment of
allogeneic chimerism after bone marrow transplantation may provide donor-specific …

Administration of donor T cells expressing the herpes simplex–thymidine kinase (HS-tk) with
a hematopoietic stem cell (HSC) transplantation could allow, if graft-versus-host disease …

Background. Rodents and dogs conditioned with total-lymphoid irradiation (TLI), with or
without antithymocyte globulin (ATG), have been shown to develop mixed chimerism and …

It has indeed been a distinct honor to be the recipient of the 2002 Outstanding Scientific
Achievement Award, and I was happy to accept it, on behalf of the entire islet transplant field …

Transplantation of allogeneic pancreatic islets for the treatment of patients with Type 1
diabetes mellitus (T1DM) is now a reality. The steady progress that has allowed for the …

Background. To date, several single-and multicenter clinical trials have attempted to induce
specific immunological unresponsiveness using donor bone marrow cell infusions to …

BACKGROUND: Heart–lung transplantation (Tx) is known to offer a protective effect against
acute cardiac rejection. This study was undertaken to evaluate acute and chronic heart …

Objectives: To describe the effect of the splenic allograft in human multivisceral
transplantation. Summary Background Data: We performed transplants of the spleen as part …

A major end point of nonmyeloablative hematopoietic stem cell transplantation is the
attainment of either mixed chimerism or full donor hematopoiesis. Because the majority of …