[HTML][HTML] Tumor microenvironment and its implications for antitumor immunity in cholangiocarcinoma: Future perspectives for novel therapies

H Cao, T Huang, M Dai, X Kong, H Liu… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
The incidence of cholangiocarcinoma (CCA) has been increasing over the past few years.
Although there are surgery, chemotherapy and other conventional treatment methods, the …

Heterogeneity of cholangiocarcinoma immune biology

F Vita, I Olaizola, F Amato, C Rae, S Marco… - Cells, 2023 - mdpi.com
Cholangiocarcinomas (CCAs) are aggressive tumors arising along the biliary tract
epithelium, whose incidence and mortality are increasing. CCAs are highly desmoplastic …

Cordycepin: A review of strategies to improve the bioavailability and efficacy

M Chen, J Luo, W Jiang, L Chen, L Miao… - Phytotherapy …, 2023 - Wiley Online Library
Cordycepin is a bioactive compound extracted from Cordyceps militaris. As a natural
antibiotic, cordycepin has a wide variety of pharmacological effects. Unfortunately, this …

Tumor immune microenvironment and the current immunotherapy of cholangiocarcinoma

S Yang, R Zou, Y Dai, Y Hu, F Li… - … Journal of Oncology, 2023 - spandidos-publications.com
Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy originating from the
epithelial system of the bile ducts, and its incidence in recent years is steadily increasing …

Significance of TRAIL/Apo-2 ligand and its death receptors in apoptosis and necroptosis signalling: Implications for cancer-targeted therapeutics

A Maji, A Paul, A Sarkar, S Nahar, R Bhowmik… - Biochemical …, 2024 - Elsevier
The human immune defense system routinely expresses the tumour necrosis factor (TNF)-
related apoptosis-inducing ligand (TRAIL), which is the most prevalent element for antitumor …

Enhancing cancer immunotherapy using cordycepin and Cordyceps militaris extract to sensitize cancer cells and modulate immune responses

C Thepmalee, P Jenkham, B Ramwarungkura… - Scientific Reports, 2024 - nature.com
Integrating immunotherapy with natural compounds holds promise in enhancing the immune
system's ability to eliminate cancer cells. Cordyceps militaris, a traditional Chinese medicine …

[HTML][HTML] Tumor immune microenvironment in intrahepatic cholangiocarcinoma: Regulatory mechanisms, functions, and therapeutic implications

AD Ricci, A Rizzo, A Schirizzi, R D'Alessandro, G Frega… - Cancers, 2024 - mdpi.com
Abstract Treatment options for intrahepatic cholangiocarcinoma (iCCA), a highly malignant
tumor with poor prognosis, are limited. Recent developments in immunotherapy and …

Cordycepin remodels the tumor microenvironment of colorectal cancer by down-regulating the expression of PD-L1

S Wu, W Fang, L Chen, C Feng, R Chen, H Ying… - Journal of Cancer …, 2023 - Springer
Purpose Colorectal cancer, as a common malignant tumor, poses a serious threat to human
life. Cordycepin, derived from Cordyceps militari s extract, which was established as a …

Cordycepin as a metabolite with pharmacological potential: A review

S Sharma, K Madaan, R Kaur - International Journal of …, 2022 - dl.begellhouse.com
The pharmacological values of Cordyceps spp. are substantially associated with the
existence of an extremely potent biometabolite: cordycepin. This component exhibits …

[HTML][HTML] Single-cell RNA sequencing indicates cordycepin remodels the tumor immune microenvironment to enhance TIGIT blockade's anti-tumor effect in colon …

R Chen, C Feng, L Chen, X Zheng, W Fang… - International …, 2024 - Elsevier
Both preclinical and clinical studies have extensively proven the effectiveness of TIGIT
inhibitors in tumor immunotherapy. However, it has been discovered that the presence of …