Non-invasive assays of cochlear synaptopathy–candidates and considerations

HM Bharadwaj, AR Mai, JM Simpson, I Choi, MG Heinz… - Neuroscience, 2019 - Elsevier
Studies in multiple species, including in post-mortem human tissue, have shown that normal
aging and/or acoustic overexposure can lead to a significant loss of afferent synapses …

Characterizing a joint reflection-distortion OAE profile in humans with endolymphatic hydrops

S Stiepan, CA Shera, C Abdala - Ear and Hearing, 2023 - journals.lww.com
Objectives: Endolymphatic hydrops (EH), a hallmark of Meniere disease, is an inner-ear
disorder where the membranes bounding the scala media are distended outward due to an …

An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone

J Chan, N Ali, A Najafi, A Meehan, LR Mancl… - Nature biomedical …, 2022 - nature.com
Otoacoustic emissions (OAEs) provide information about the function of the outer hair cells
of the cochlea. In high-income countries, infants undergo OAE tests as part of the screening …

Association between hearing sensitivity and dopamine transporter availability in Parkinson's disease

E Garasto, A Stefani, M Pierantozzi… - Brain …, 2023 - academic.oup.com
In a previous study, we observed:(i) significant hearing function impairment, assessed with
pure tone audiometry and distortion product otoacoustic emissions, in patients with …

Stimulus-frequency otoacoustic emissions and middle-ear pressure gains in a finite-element mouse model

H Motallebzadeh, S Puria - The Journal of the Acoustical Society of …, 2022 - pubs.aip.org
For evoked otoacoustic emissions (OAEs), the stimulus and emission signals traverse the
middle ear (ME) in forward and reverse directions, respectively. In this study, a fully coupled …

Characterizing the relationship between reflection and distortion otoacoustic emissions in normal-hearing adults

C Abdala, P Luo, CA Shera - Journal of the Association for Research in …, 2022 - Springer
Otoacoustic emissions (OAEs) arise from one (or a combination) of two basic generation
mechanisms in the cochlea: nonlinear distortion and linear reflection. As a result of having …

Ultra-high frequency distortion product otoacoustic emissions for detection of hearing loss and tinnitus

WW Jedrzejczak, E Pilka, M Ganc, K Kochanek… - International Journal of …, 2022 - mdpi.com
Several studies have suggested that distortion product otoacoustic emissions (DPOAEs)
may be an early marker not only of hearing loss (HL) but also of tinnitus. The purpose of this …

Incorporating evanescent modes and flow losses into reference impedances in acoustic Thévenin calibration

KR Nørgaard, E Fernandez-Grande… - The Journal of the …, 2017 - pubs.aip.org
This paper proposes an alternative approach to acoustic Thévenin calibration of an ear
probe. An existing methodology derives the Thévenin-equivalent source parameters from …

Swept-tone stimulus-frequency otoacoustic emissions in human newborns

C Abdala, P Luo, Y Guardia - Trends in Hearing, 2019 - journals.sagepub.com
Several types of otoacoustic emissions have been characterized in newborns to study the
maturational status of the cochlea at birth and to develop effective tests of hearing. The …

Cross-species experiments reveal widespread cochlear neural damage in normal hearing

HM Bharadwaj, AR Hustedt-Mai, HM Ginsberg… - Communications …, 2022 - nature.com
Animal models suggest that cochlear afferent nerve endings may be more vulnerable than
sensory hair cells to damage from acoustic overexposure and aging. Because neural …