The aim of the study was to characterize the biopharmaceutics classification system (BCS)
category of apigenin (AP) using intrinsic dissolution rate (IDR) and rat intestinal permeability …

Background The luminal surface of the small intestine is composed of a monolayer of cells
overlying a lamina propria comprised of extracellular matrix (ECM) proteins. The ECM …

Diclofenac is an extensively used nonsteroidal anti-inflammatory drug, but gastrointestinal
liabilities and cardiovascular complications take the shine away from such a widely …

Rapamycin as a novel macrolide immunosuppressive agent has been commonly used in
organ transplantation owing to its stronger immunosuppressive effect, non-nephrotoxicity …

Animal models are frequently used for in vitro physiologic and drug transport studies of the
colon, but there exists significant pressure to improve assay throughput as well as to achieve …

In this study, the quantitative determination of phenol red with using HPLC, the permeability
marker widely used in gastrointestinal studies, and its stability in various apolar phase …

Background The intestinal epithelium is a major site of drug metabolism in the human body,
possessing enterocytes that house brush border enzymes and phase I and II drug …

Abstract Objectives According to Biopharmaceutics Classification System (BCS), acyclovir is
a class III (high solubility, low permeability) compound, and it is transported through …

The vast majority of marketed drugs are orally administrated. As such, drug absorption is
one of the important drug metabolism and pharmacokinetics parameters that should be …

Intestinal permeability is a key biopharmaceutical variable in pharmaceutical research and
development, and regulatory assessment. In situ rat models are often used to predict the …