Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian
cell nuclei. These structures play a role in regulating the expression of certain genes in …

Whole genome transcriptomic analyses have identified large numbers of dynamically
expressed long non-protein-coding RNAs (lncRNAs) in mammals and other animals whose …

To the Editor: Transcription is inherently stochastic even in clonal cell populations1. Studies
at the single-cell, single-molecule level enable a quantitative understanding of the …

Large numbers of long RNAs with little or no protein-coding potential [long noncoding RNAs
(lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the …

The past few years have revealed that the genomes of all studied eukaryotes are almost
entirely transcribed, generating an enormous number of non–protein-coding RNAs …

Non-protein-coding sequences increasingly dominate the genomes of multicellular
organisms as their complexity increases, in contrast to protein-coding genes, which remain …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Genomic imprinting causes genes to be expressed or repressed depending on their
parental origin. The majority of imprinted genes identified to date map in clusters and much …

Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin
space of mammalian cells. They are RNA-protein structures formed by the interaction …

Imprinted genes play crucial roles in mammalian development and disruption of their
expression is associated with many human disorders including tumourigenesis; yet, the …