Background: Nuclear factor ΚB (NF-ΚB) comprises a family of proteins that act as
transcription factors promoting the expression of many genes. Activation of NF-ΚB …

Background: Indicaxanthin, a betaxanthin belonging to the betalain class of compounds, has
been recently demonstrated to exert significant antiproliferative effects inducing apoptosis of …

Protein kinases constitute attractive therapeutic targets for development of new prototypes to
treat different chronic diseases. Several available drugs, like tinibs, are tyrosine kinase …

Herein, we present the design, synthesis and trypanocidal evaluation of sixteen new 1, 3, 4-
thiadiazole derivatives from N-aminobenzyl or N-arylhydrazone series. All derivatives were …

LASSBio-1524 was designed as inhibitor of the IKK-β (kappa β kinase inhibitor) enzyme,
which participates in the activation of the nuclear factor κB (NF-κB) canonical pathway, and …

Aims The main aim of this paper was the synthesis and the evaluation of the anti-
inflammatory activity of LASSBio-1828 (an amino-pyridinyl-N-acylhydrazone) and its …

In this study, we synthesized a new congener series of N-sulphonylhydrazones designed as
candidate ROCK inhibitors using the molecular hybridization of the clinically approved drug …

Immunosuppressive drugs are widely used for the treatment of immune-mediated diseases
and inflammation, but the toxicity and side effects of the available immunosuppressors make …

Design, synthesis, biological evaluation, and molecular modeling of inhibitors of enzymes
involved in tumor and viral pathologie Page 1 UNIVERSITY OF MESSINA Department of …

RESUMO Silva Fernandes Grazielle.“Novo inibidor de MAPK p38α reduz disfunção
ventricular induzida pela hipertensão arterial pulmonar em ratos”. Rio de Janeiro, 2020 …