A decade ago, we hypothesized that drug addiction can be viewed as a transition from
voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by …

This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …

Cues associated with rewards, such as food or drugs of abuse, can themselves acquire
motivational properties. Acting as incentive stimuli, such cues can exert powerful control …

Memories are not static imprints of past experience, but rather are dynamic entities which
enable us to predict outcomes of future situations and inform appropriate behaviours. In …

Relapse to alcohol abuse is an important clinical issue that is frequently caused by cue-
induced drug craving. Therefore, disruption of the memory for the cue-alcohol association is …

Currently, there are no approved pharmacotherapies for addiction to cocaine and other
psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a …

Since the introduction of intravenous drug self-administration methodology over 50 years
ago, experimental investigation of addictive behaviour has delivered an enormous body of …

Background Consolidated memories can undergo enduring modification through retrieval-
dependent treatments that modulate reconsolidation. This represents a potentially …

Interfering with memory reconsolidation has valuable potential to be used as a treatment for
maladaptive memories and psychiatric disorders. Numerous studies suggest that …

Recent research suggests that the mere act of retrieving a memory can temporarily make
that memory vulnerable to disruption. This process of “reconsolidation” will typically …