Pancreatic cancer (PC), characterized by its dense desmoplastic stroma and
hypovascularity, is one of the most lethal cancers with a poor prognosis in the world …

Generating porcine embryos in vitro is a critical process for creating genetically modified
pigs as agricultural and biomedical models; however, these embryo technologies have been …

Pancreatic cancer is a malignant disease associated with poor survival and nearly 80%
present with unresectable tumors. Treatments such as chemotherapy and radiation therapy …

Objective New therapeutic strategies and paradigms are direly needed to treat pancreatic
cancer. The absence of a suitable pre-clinical animal model of pancreatic cancer is a major …

The efficiency of electroporation treatments depends on the application of a critical electric
field over the targeted tissue volume. Both the electric field and temperature distribution …

Histotripsy is an emerging noninvasive, non-thermal, and non-ionizing focused ultrasound
(US) therapy that can be used to destroy targeted tissue. Histotripsy has evolved from early …

Pancreatic tumors can be resistant to drug penetration due to high interstitial fluid pressure,
dense stroma, and disarrayed vasculature. Ultrasound-induced cavitation is an emerging …

Abstract Growth differentiation factor 9 (GDF9) is a secreted protein belonging to the
transforming growth factor beta superfamily and has been well characterized for its role …

New therapeutic strategies are direly needed in the fight against cancer. Over the last
decade, several tumor ablation strategies have emerged as stand-alone or combination …

Swine biomedical models have been gaining in popularity over the last decade, particularly
for applications in oncology research. Swine models for cancer research include pigs that …