Environmental enrichment in murine models and its translation to human factors improving conditions in Alzheimer disease
MF Colavitta, L Grasso, FJ Barrantes - The Journal of Prevention of …, 2023 - Springer
With the aging of the world population, there has been a notable increase in the incidence of
Alzheimer disease (AD), the most prevalent neurodegenerative disease affecting the elderly …
Alzheimer disease (AD), the most prevalent neurodegenerative disease affecting the elderly …
Transgenic mouse models as tools for understanding how increased cognitive and physical stimulation can improve cognition in Alzheimer's disease
A Shepherd, TD Zhang… - Brain …, 2018 - content.iospress.com
Cognitive decline appears as a core feature of dementia, of which the most prevalent form,
Alzheimer's disease (AD) affects more than 45 million people worldwide. There is no cure …
Alzheimer's disease (AD) affects more than 45 million people worldwide. There is no cure …
Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched …
V Cattaud, C Bezzina, CC Rey, C Lejards, L Dahan… - Neurobiology of …, 2018 - Elsevier
Recent findings show that parvalbumin (PV) interneuron function is impaired in Alzheimer's
disease (AD), and that this impairment in PV function can be linked to network dysfunction …
disease (AD), and that this impairment in PV function can be linked to network dysfunction …
Differential roles of environmental enrichment in Alzheimer's type of neurodegeneration and physiological aging
VV Salmin, YK Komleva, NV Kuvacheva… - Frontiers in Aging …, 2017 - frontiersin.org
Impairment of hippocampal adult neurogenesis in aging or degenerating brain is a well-
known phenomenon caused by the shortage of brain stem cell pool, alterations in the local …
known phenomenon caused by the shortage of brain stem cell pool, alterations in the local …
Neuronal hyperexcitability in the Tg2576 mouse model of Alzheimer's disease–the influence of sleep and noradrenergic transmission
The link between Alzheimer's disease (AD) and network hypersynchrony–manifesting as
epileptic activities–received considerable attention in the past decade. However, several …
epileptic activities–received considerable attention in the past decade. However, several …
Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for …
There is common agreement that many disorders of the central nervous system are
'complex', that is, there are many potential factors that influence the development of the …
'complex', that is, there are many potential factors that influence the development of the …
Recommendations for preclinical testing of treatments against Alzheimer's disease-related epileptiform spikes in transgenic rodent models
N Jin, C Babiloni, WH Drinkenburg… - Journal of …, 2022 - content.iospress.com
Recent evidence suggests that about 30% of patients with mild to moderate Alzheimer's
disease (AD) without a known diagnosis of epilepsy may display epileptiform spikes during …
disease (AD) without a known diagnosis of epilepsy may display epileptiform spikes during …
Technology-aided programs to support positive verbal and physical engagement in persons with moderate or severe Alzheimer's disease
Pilot studies using technology-aided programs to promote verbal reminiscence and mild
physical activity (ie, positive forms of engagement) in persons with moderate or severe …
physical activity (ie, positive forms of engagement) in persons with moderate or severe …
Enriched Environment Rescues Impaired Sleep–Wake Architecture and Abnormal Neural Dynamics in Chronic Epileptic Rats
Sleep dysfunctions in epilepsy increase the burden of seizures and cognitive impairments.
Seizures and certain anti-seizure drugs (ASDs) can affect sleep quality, leading to excessive …
Seizures and certain anti-seizure drugs (ASDs) can affect sleep quality, leading to excessive …
Human and animal models for translational research on neurodegeneration: challenges and opportunities from South America
Facing the alarming growth of dementia and neurodegenerative conditions has become a
critical priority across the globe (Alzheimer's Disease International, 2009; Lancet, 2015; …
critical priority across the globe (Alzheimer's Disease International, 2009; Lancet, 2015; …