Environmental enrichment in murine models and its translation to human factors improving conditions in Alzheimer disease

MF Colavitta, L Grasso, FJ Barrantes - The Journal of Prevention of …, 2023 - Springer
With the aging of the world population, there has been a notable increase in the incidence of
Alzheimer disease (AD), the most prevalent neurodegenerative disease affecting the elderly …

Transgenic mouse models as tools for understanding how increased cognitive and physical stimulation can improve cognition in Alzheimer's disease

A Shepherd, TD Zhang… - Brain …, 2018 - content.iospress.com
Cognitive decline appears as a core feature of dementia, of which the most prevalent form,
Alzheimer's disease (AD) affects more than 45 million people worldwide. There is no cure …

Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched …

V Cattaud, C Bezzina, CC Rey, C Lejards, L Dahan… - Neurobiology of …, 2018 - Elsevier
Recent findings show that parvalbumin (PV) interneuron function is impaired in Alzheimer's
disease (AD), and that this impairment in PV function can be linked to network dysfunction …

Differential roles of environmental enrichment in Alzheimer's type of neurodegeneration and physiological aging

VV Salmin, YK Komleva, NV Kuvacheva… - Frontiers in Aging …, 2017 - frontiersin.org
Impairment of hippocampal adult neurogenesis in aging or degenerating brain is a well-
known phenomenon caused by the shortage of brain stem cell pool, alterations in the local …

Neuronal hyperexcitability in the Tg2576 mouse model of Alzheimer's disease–the influence of sleep and noradrenergic transmission

AB Szabo, V Cattaud, C Bezzina, RF Dard… - Neurobiology of …, 2023 - Elsevier
The link between Alzheimer's disease (AD) and network hypersynchrony–manifesting as
epileptic activities–received considerable attention in the past decade. However, several …

Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for …

HE Scharfman, AM Kanner, A Friedman, I Blümcke… - Epilepsy & behavior, 2018 - Elsevier
There is common agreement that many disorders of the central nervous system are
'complex', that is, there are many potential factors that influence the development of the …

Recommendations for preclinical testing of treatments against Alzheimer's disease-related epileptiform spikes in transgenic rodent models

N Jin, C Babiloni, WH Drinkenburg… - Journal of …, 2022 - content.iospress.com
Recent evidence suggests that about 30% of patients with mild to moderate Alzheimer's
disease (AD) without a known diagnosis of epilepsy may display epileptiform spikes during …

Technology-aided programs to support positive verbal and physical engagement in persons with moderate or severe Alzheimer's disease

GE Lancioni, NN Singh, MF O'Reilly… - Frontiers in aging …, 2016 - frontiersin.org
Pilot studies using technology-aided programs to promote verbal reminiscence and mild
physical activity (ie, positive forms of engagement) in persons with moderate or severe …

Enriched Environment Rescues Impaired Sleep–Wake Architecture and Abnormal Neural Dynamics in Chronic Epileptic Rats

KP Nair, RJ Salaka, BN Srikumar, BM Kutty, BSS Rao - Neuroscience, 2022 - Elsevier
Sleep dysfunctions in epilepsy increase the burden of seizures and cognitive impairments.
Seizures and certain anti-seizure drugs (ASDs) can affect sleep quality, leading to excessive …

Human and animal models for translational research on neurodegeneration: challenges and opportunities from South America

A Ibáñez, L Sedeño, AM García… - Frontiers in Aging …, 2018 - frontiersin.org
Facing the alarming growth of dementia and neurodegenerative conditions has become a
critical priority across the globe (Alzheimer's Disease International, 2009; Lancet, 2015; …