DNA double-strand breaks (DSBs) are the most lethal DNA damages which lead to severe
genome instability. Phosphorylation is one of the most important protein post-translation …

The development of the mammalian cerebral cortex involves a series of mechanisms: from
patterning, progenitor cell proliferation and differentiation, to neuronal migration. Many …

The retinoblastoma (RB) tumor suppressor is recognized as a master regulator that controls
entry into the S phase of the cell cycle. Its loss leads to uncontrolled cell proliferation and is a …

Telomeres protect chromosome ends from inappropriately activating the DNA damage and
repair responses. Primary microcephaly is a key clinical feature of several human telomere …

Abstract Cullin-RING E3-Ligases (CRLs), the largest family of E3 ubiquitin-Ligases, regulate
diverse cellular processes by promoting ubiquitination of target proteins. The evolutionarily …

Abstract Microcephalin 1 (MCPH1) was identified from genetic mutations in patients with
primary autosomal recessive microcephaly. In response to DNA double-strand breaks …

Ataxia-telangiectasia (AT) and Nijmegen breakage syndrome (NBS) are well-known single-
gene disorders, which have similar cellular phenotypes, including chromosome instability …

目的探讨DNA 损伤修复蛋白乳腺癌易感基因-1 (BRCA1) 和拓扑异构酶Ⅱβ 结合蛋白1
(TopBP1) 表达与非小细胞肺癌(non-small cell lung cancer, NSCLC) 含铂方案疗效的相关性 …

Mutations in the N-terminal region of MCPH1/BRIT1 cause premature chromosome
condensation (PCC), whereby cells enter mitosis before completing DNA replication. 792 …

Results.......................................................................................................................... 60 Mutation of
Serine 1333 alters ATR kinase activity............................................. 60 S1333 is unlikely to be …