All mammalian cell membranes contain cholesterol to maintain membrane integrity. The
transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially …

Human genetics research has discovered thousands of proteins associated with complex
and rare diseases. Genome-wide association studies (GWAS) and studies of Mendelian …

We developed an endophenotype disease module-based methodology for Alzheimer's
disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier …

Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk
factors throughout the life course. However, robust evidence for most of these risk factors is …

Background Some observational studies found that dyslipidaemia is a risk factor for non-
alcoholic fatty liver disease (NAFLD), and lipid-lowering drugs may lower NAFLD risk …

Abstract Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary
heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from …

Background: Lipid metabolism plays an important role in viral infections. We aimed to
assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors, and …

Aims As the potential impact of statins on cognitive decline and dementia is still debated, we
conducted a meta-analysis of observational studies to examine the effect of statin use on the …

Background Lipid-lowering therapy with statins and proprotein convertase subtilisin/kexin
type 9 (PCSK9) inhibition are effective strategies in reducing cardiovascular disease risk; …

Proprotein convertase subtilisin/kexin type 9 (PCSK9), mainly synthetized and released by
the liver, represents one of the key regulators of low-density lipoprotein cholesterol …