Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation

KS McDowell, F Vadakkumpadan, R Blake, J Blauer… - Biophysical journal, 2013 - cell.com
Atrial fibrillation (AF), the most common arrhythmia in humans, is initiated when triggered
activity from the pulmonary veins propagates into atrial tissue and degrades into reentrant …

Methodology for patient-specific modeling of atrial fibrosis as a substrate for atrial fibrillation

KS McDowell, F Vadakkumpadan, R Blake… - Journal of …, 2012 - Elsevier
Personalized computational cardiac models are emerging as an important tool for studying
cardiac arrhythmia mechanisms, and have the potential to become powerful instruments for …

[HTML][HTML] A Review of Personalised Cardiac Computational Modelling Using Electroanatomical Mapping Data

OA Jaffery, L Melki, G Slabaugh, WW Good… - Arrhythmia & …, 2024 - ncbi.nlm.nih.gov
Computational models of cardiac electrophysiology have gradually matured during the past
few decades and are now being personalised to provide patient-specific therapy guidance …

An efficient finite element approach for modeling fibrotic clefts in the heart

CM Costa, FO Campos, AJ Prassl… - IEEE Transactions …, 2013 - ieeexplore.ieee.org
Advanced medical imaging technologies provide a wealth of information on cardiac
anatomy and structure at a paracellular resolution, allowing to identify microstructural …

Modeling dynamics in diseased cardiac tissue: Impact of model choice

TA Gokhale, E Medvescek… - Chaos: An Interdisciplinary …, 2017 - pubs.aip.org
Cardiac arrhythmias have been traditionally simulated using continuous models that
assume tissue homogeneity and use a relatively large spatial discretization. However, it is …

Bridging Scales: How Microstructural Features Impact Macroscopic Cardiac Propagation

TA Gokhale - 2018 - search.proquest.com
Cardiac arrhythmias such as atrial fibrillation and ventricular tachycardia are closely
associated with microscopic fibrotic changes in cardiac structure that result in a …

[图书][B] The mechanistic role of fibrosis in cardiac arrhythmogenesis

KS McDowell - 2013 - search.proquest.com
Myocardial fibrosis is associated with both ventricular and atrial arrhythmias, however the
underlying mechanisms that link fibrotic remodeling to arrhythmogenesis are not well …