Cilia have multiple functions in the development of the entire organism, and participate in
the development and functioning of the central nervous system. In the last decade, studies …

Neurodegenerative illness develops as a result of genetic defects that cause changes at
numerous levels, including genomic products and biological processes. It entails the …

Primary cilia are compartmentalized sensory organelles present on the majority of neurons
in the mammalian brain throughout adulthood. Recent evidence suggests that cilia regulate …

Cilia are dynamic microtubule-based organelles present on the surface of many eukaryotic
cell types and can be motile or non-motile primary cilia. Cilia defects underlie a growing list …

Collateral branches from axons are key components of functional neural circuits that allow
neurons to connect with multiple synaptic targets. Like axon growth and guidance, formation …

Stress activates the nuclear translocation of glucocorticoid receptors (GR) to trigger gene
expression. Abnormal GR levels can alter the stress responses in animals and therapeutic …

Parkinson's disease (PD) is a neurodegenerative disease with an impairment of movement
execution that is related to age and genetic and environmental factors. 1-methyl-4-phenyl-1 …

Abstract Phosphodiesterase 7 (PDE7), one of the 11 phosphodiesterase (PDE) families,
specifically hydrolyzes cyclic 3′, 5′-adenosine monophosphate (cAMP). PDE7 is involved …

Background PDEs regulate cAMP levels which is critical for PKA activity-dependent
activation of CREB-mediated transcription in learning and memory. Inhibitors of PDEs like …

Background Autism is usually conceptualized as a disorder or disease that involves
fundamentally abnormal neurodevelopment. In the present work, the hypothesis that a suite …