Purinergic signaling regulates many metabolic functions and is implicated in liver physiology
and pathophysiology. Liver functionality is modulated by ionotropic P2X and metabotropic …

Excess consumption of carbohydrates, fat and calories leads to non‐alcoholic fatty liver
disease (NAFLD) and hepatic insulin resistance; these are major factors in the pathogenesis …

Emerging evidence discloses the involvement of calcium channel protein in the pathological
process of liver diseases. Transient receptor potential cation channel subfamily C member 3 …

Rapid breakdown of hepatic glycogen stores into glucose plays an important role during
intense physical exercise to maintain systemic euglycemia. Hepatic glycogenolysis is …

In this issue of Function, Gaspers et al. 1 show that ethanol, in pathophysiologically relevant
concentrations, can reduce the frequency and magnitude of hormone-induced Ca2þ …

Looking ahead In summary, the authors demonstrated that HFD hepatocytes required a 10-
fold higher NA concentration to obtain the half-maximal effective concentration of NA …

Changes in cytosolic Ca2+ concentration ([Ca2+] c) serve as an almost ubiquitous signal in
organisms across the four kingdoms of Eukaryota, and perhaps in some prokaryotes of …