[HTML][HTML] Akt: A potential drug target for metabolic syndrome
R Miao, X Fang, J Wei, H Wu, X Wang… - Frontiers in Physiology, 2022 - frontiersin.org
The serine/threonine kinase Akt, also known as protein kinase B (PKB), is one of the key
factors regulating glucose and lipid energy metabolism, and is the core focus of current …
factors regulating glucose and lipid energy metabolism, and is the core focus of current …
What bacteria want
MY Galperin - Environmental microbiology, 2018 - Wiley Online Library
Bacterial signal transduction systems are responsible for sensing environmental cues and
adjusting the cellular behaviour and/or metabolism in response to these cues. They also …
adjusting the cellular behaviour and/or metabolism in response to these cues. They also …
[HTML][HTML] Nitric oxide signaling in ctenophores
Nitric oxide (NO) is one of the most ancient and versatile signal molecules across all
domains of life. NO signaling might also play an essential role in the origin of animal …
domains of life. NO signaling might also play an essential role in the origin of animal …
[HTML][HTML] Structure and function of adenylyl cyclases, key enzymes in cellular signaling
The adenylyl cyclases (ACs) catalyze the production of the ubiquitous second messenger,
cAMP, which in turns acts on a number of effectors and thus regulates a plethora of cellular …
cAMP, which in turns acts on a number of effectors and thus regulates a plethora of cellular …
[HTML][HTML] The role of solute binding proteins in signal transduction
The solute binding proteins (SBPs) of prokaryotes are present in the extracytosolic space.
Although their primary function is providing substrates to transporters, SBPs also stimulate …
Although their primary function is providing substrates to transporters, SBPs also stimulate …
[HTML][HTML] The plasma membrane: a platform for intra-and intercellular redox signaling
DE Nordzieke, I Medraño-Fernandez - Antioxidants, 2018 - mdpi.com
Membranes are of outmost importance to allow for specific signal transduction due to their
ability to localize, amplify, and direct signals. However, due to the double-edged nature of …
ability to localize, amplify, and direct signals. However, due to the double-edged nature of …
[HTML][HTML] The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission
Nitric oxide (NO) is a ubiquitous gaseous messenger, but we know little about its early
evolution. Here, we analyzed NO synthases (NOS) in four different species of placozoans …
evolution. Here, we analyzed NO synthases (NOS) in four different species of placozoans …
[HTML][HTML] PDE-mediated cyclic nucleotide compartmentation in vascular smooth muscle cells: from basic to a clinical perspective
Cardiovascular diseases are important causes of mortality and morbidity worldwide.
Vascular smooth muscle cells (SMCs) are major components of blood vessels and are …
Vascular smooth muscle cells (SMCs) are major components of blood vessels and are …
[HTML][HTML] Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling
X Zhou, VE Torres - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic
prevalence between 1: 400 and 1: 1,000 individuals, is the third most common cause of end …
prevalence between 1: 400 and 1: 1,000 individuals, is the third most common cause of end …
[HTML][HTML] cAMP Compartmentalization in cerebrovascular endothelial cells: new therapeutic opportunities in Alzheimer's disease
D Viña, N Seoane, EC Vasquez, M Campos-Toimil - Cells, 2021 - mdpi.com
The vascular hypothesis used to explain the pathophysiology of Alzheimer's disease (AD)
suggests that a dysfunction of the cerebral microvasculature could be the beginning of …
suggests that a dysfunction of the cerebral microvasculature could be the beginning of …