The etiology of ischemic stroke is multifactorial. Although receiving less emphasis, genetic
causes make a significant contribution to ischemic stroke genesis, especially in early-onset …

Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …

Iterative advances in understanding of the genetics of type 1 diabetes have identified> 70
genetic regions associated with risk of the disease, including strong associations across the …

Despite the rapid progress in diagnosis and treatment of cardiovascular disease (CVD), this
disease remains a major cause of mortality and morbidity. Recent progress over the last two …

Early identification of genetic risk factors for complex diseases can enable timely
interventions and prevent serious outcomes, including mortality. While the genetics …

Single nucleotide polymorphisms (SNPs) are the most abundant type of genomic variation
and the most accessible to genotype in large cohorts. However, they individually explain a …

Importance Patients with juvenile idiopathic arthritis (JIA) may develop adult rheumatic
diseases later in life, and prolonged or recurrent disease activity is often associated with …

A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …

A strong genetic background for psychoses is well-established. Most individuals with a high
genetic risk for schizophrenia, however, do not develop the disorder. We investigated …

Background Rheumatoid arthritis (RA) shares genetic variants with other autoimmune
conditions, but existing studies test the association between RA variants with a pre-defined …