Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Background Doxorubicin-induced cardiotoxicity (DIC) limits the clinical application of the
drug in treatment of cancers and imposes a severe health burden on the patients. Therefore …

Doxorubicin (DOXO) is a potent chemotherapeutic drug widely used to treat various cancers.
However, its clinical application is limited due to serious adverse effects on dose-dependent …

Mitochondrial aconitase (ACO2) has been postulated as a redox sensor in the tricarboxylic
acid cycle. Its high sensitivity towards reactive oxygen and nitrogen species is due to its …

Pathological cardiac hypertrophy is a considerable contributor to global disease burden.
Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since …

Doxorubicin (DOX) is broadly used as a medication for cancer treatment. However, DOX has
been connected with chemotherapy-related complications, for instance, cognitive …

Anthracyclines are effective anticancer drugs; however, their use is restricted because of
their dose-dependent, time-dependent and irreversible myocardial toxicity. The mechanism …

Chemotherapy-induced memory loss (“chemobrain”) can occur following treatment with the
widely used chemotherapeutic agent doxorubicin (DOX). However, the mechanisms through …

Friedreich's ataxia (FRDA) is a degenerative disease caused by a decrease in the
mitochondrial protein frataxin (Fxn), which is involved in iron–sulfur cluster (ISC) synthesis …

Recent evidence suggests that ferroptosis, an iron-facilitated cell death with excessive lipid
peroxidation, is a critical mechanism underlying doxorubicin (DOX)-induced cardiotoxicity …