The mechanism of ferroptosis and its related diseases

S Feng, D Tang, Y Wang, X Li, H Bao, C Tang… - Molecular …, 2023 - Springer
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway

H Chen, J Zhu, Y Le, J Pan, Y Liu, Z Liu, C Wang… - Phytomedicine, 2022 - Elsevier
Background Doxorubicin-induced cardiotoxicity (DIC) limits the clinical application of the
drug in treatment of cancers and imposes a severe health burden on the patients. Therefore …

Fucoidan protects against doxorubicin-induced cardiotoxicity by reducing oxidative stress and preventing mitochondrial function injury

Y Ji, D Jin, J Qi, X Wang, C Zhang, P An, Y Luo… - International Journal of …, 2022 - mdpi.com
Doxorubicin (DOXO) is a potent chemotherapeutic drug widely used to treat various cancers.
However, its clinical application is limited due to serious adverse effects on dose-dependent …

[HTML][HTML] Redox sensitive human mitochondrial aconitase and its interaction with frataxin: In vitro and in silico studies confirm that it takes two to tango

S Mansilla, V Tórtora, F Pignataro, S Sastre… - Free Radical Biology …, 2023 - Elsevier
Mitochondrial aconitase (ACO2) has been postulated as a redox sensor in the tricarboxylic
acid cycle. Its high sensitivity towards reactive oxygen and nitrogen species is due to its …

[HTML][HTML] Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage

DJY Hsieh, BCK Tsai, P Barik, MA Shibu… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Pathological cardiac hypertrophy is a considerable contributor to global disease burden.
Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since …

Pioglitazone ameliorates DOX-induced cognitive impairment by mitigating inflammation, oxidative stress, and apoptosis of hippocampal neurons in rats

AH Alhowail - Behavioural Brain Research, 2024 - Elsevier
Doxorubicin (DOX) is broadly used as a medication for cancer treatment. However, DOX has
been connected with chemotherapy-related complications, for instance, cognitive …

[HTML][HTML] Exploring Anthracycline-Induced Cardiotoxicity from the Perspective of Protein Quality Control

S Li, W Niu, C Wang, J Zhao, N Zhang, Y Yin… - Reviews in …, 2024 - imrpress.com
Anthracyclines are effective anticancer drugs; however, their use is restricted because of
their dose-dependent, time-dependent and irreversible myocardial toxicity. The mechanism …

Phenyl-2-aminoethyl selenide ameliorates hippocampal long-term potentiation and cognitive deficits following doxorubicin treatment

AH Alhowail, M Eggert, J Bloemer, PD Pinky, L Woodie… - Plos one, 2023 - journals.plos.org
Chemotherapy-induced memory loss (“chemobrain”) can occur following treatment with the
widely used chemotherapeutic agent doxorubicin (DOX). However, the mechanisms through …

Posttranslational regulation of mitochondrial frataxin and identification of compounds that increase frataxin levels in Friedreich's ataxia

PT Hackett, X Jia, L Li, DM Ward - Journal of Biological Chemistry, 2022 - ASBMB
Friedreich's ataxia (FRDA) is a degenerative disease caused by a decrease in the
mitochondrial protein frataxin (Fxn), which is involved in iron–sulfur cluster (ISC) synthesis …

Protective Role of Dioscin against Doxorubicin-Induced Chronic Cardiotoxicity: Insights from Nrf2-GPX4 Axis-Mediated Cardiac Ferroptosis

J Liu, H Liu, L Deng, T Wang, L Li, Y Chen, L Qu… - Biomolecules, 2024 - mdpi.com
Recent evidence suggests that ferroptosis, an iron-facilitated cell death with excessive lipid
peroxidation, is a critical mechanism underlying doxorubicin (DOX)-induced cardiotoxicity …