[HTML][HTML] The issue of heterogeneity of MSC-based advanced therapy medicinal products–a review

AB Česnik, U Švajger - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
Mesenchymal stromal stem cells (MSCs) possess a remarkable potential for numerous
clinical applications due to their unique properties including self-renewal …

[HTML][HTML] Heterogeneity of mesenchymal stem cells as a limiting factor in their clinical application to inflammatory bowel disease in dogs and cats

T Teshima - The Veterinary Journal, 2024 - Elsevier
Inflammatory bowel disease (IBD) is a major subtype of chronic enteropathies in dogs and
cats. Conventional drugs such as immunomodulatory medicines as glucocorticoids and/or …

[HTML][HTML] Advantages of pooling of human bone marrow-derived mesenchymal stromal cells from different donors versus single-donor MSCs

S Kannan, S Gokul Krishna, PK Gupta… - Scientific Reports, 2024 - nature.com
Mesenchymal stromal cells (MSC) from adult bone marrow are the most commonly used
cells in clinical trials. MSCs from single donors are the preferred starting material but suffer …

[HTML][HTML] Human Infrapatellar Fat Pad Mesenchymal Stem Cell–derived Extracellular Vesicles Purified by Anion Exchange Chromatography Suppress Osteoarthritis …

Q Liu, J Wu, H Wang, Z Jia, G Li - Clinical Orthopaedics and …, 2024 - journals.lww.com
Background Extracellular vesicles derived from mesenchymal stem cells (MSCs) show great
promise in treating osteoarthritis (OA). However, studies from the perspective of clinical …

Relative efficacy and safety of mesenchymal stem cells for osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

X Tian, Z Qu, Y Cao, B Zhang - Frontiers in Endocrinology, 2024 - frontiersin.org
Introduction The aim of this meta-analysis was to evaluate the efficacy and safety of
mesenchymal stem cells (MSCs) for the treatment of knee osteoarthritis (OA). Methods The …

Pharmacotherapy for osteoarthritis-related pain: current and emerging therapies

M Zhang, Z Wang, C Ding - Expert Opinion on Pharmacotherapy, 2024 - Taylor & Francis
Introduction Osteoarthritis (OA) related pain has affected millions of people worldwide.
However, the current pharmacological options for managing OA-related pain have not …

Comparative Analysis of Short‐Term and Long‐Term Clinical Efficacy of Mesenchymal Stem Cells from Different Sources in Knee Osteoarthritis: A Network Meta …

QX Ding, X Wang, TS Li, YF Li, WY Li… - Stem Cells …, 2024 - Wiley Online Library
Background. Joint articular injection of mesenchymal stem cells (MSCs) has emerged as a
novel treatment approach for osteoarthritis (OA). However, the effectiveness of MSCs …

[HTML][HTML] StemOneTM/Stempeucel®: CDSCO Approved, Adult Human Bone Marrow-Derived, Cultured, Pooled, Allogenic Mesenchymal Stem Cells for Knee …

A Gupta - Biomedicines, 2023 - mdpi.com
The knee, the most likely joint to present osteoarthritis (OA), is accountable for approximately
80% of the global burden of the OA [1, 2]. The prevalence of knee OA has continued to …

[HTML][HTML] Transplantation of three mesenchymal stem cells for knee osteoarthritis, which cell and type are more beneficial? a systematic review and network meta …

X Chen, J Zheng, L Yin, Y Li, H Liu - Journal of Orthopaedic Surgery and …, 2024 - Springer
Background In knee osteoarthritis (KOA), treatments involving knee injections of bone
marrow-derived mesenchymal stem cells (BM-MSC), adipose tissue-derived mesenchymal …

[HTML][HTML] Hyaluronic acid, platelet-rich plasma, bone marrow aspirate concentrate, the stromal vascular fraction, or mesenchymal stem cells: which is the best candidate …

VB Ngoc, P Van Phuc - Biomedical Research and …, 2023 - bmrat.biomedpress.org
Regenerative medicine-based therapies are considered promising for some chronic
diseases, such as osteoarthritis (OA). Because OA is the most common disease in many …