Gap junctions provide the basis for electrical synapses between neurons. Early studies in
well-defined circuits in lower vertebrates laid the foundation for understanding various …

Identification of reliable biomarkers of prognosis in subjects with high risk to psychosis is an
essential step to improve care and treatment of this population of help-seekers. Longitudinal …

Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's
disease (AD) and several theories have been advanced to explain the relationship. A …

Metabotropic glutamate (mGlu) receptors, a family of G-protein-coupled receptors, have
been identified as novel therapeutic targets based on extensive research supporting their …

Frontotemporal dementia (FTD) is a heterogenous neurodegenerative disorder,
characterized by diverse clinical presentations, neuropathological characteristics and …

Decreased Na+, K+-ATPase (NKA) activity causes energy deficiency, which is commonly
observed in neurodegenerative diseases. The NKA is constituted of three subunits: α, β, and …

Gap junctions underlie electrical synaptic transmission between neurons. Generally
perceived as simple intercellular channels,“electrical synapses” have demonstrated to be …

Cortical oscillations are thought to be involved in many cognitive functions and processes.
Several mechanisms have been proposed to regulate oscillations. One prominent but …

Electrical synapses are the functional correlate of gap junctions and allow transmission of
small molecules and electrical current between coupled neurons. Instead of static pores …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence of
neuritic plaques and neurofibrillary tangles. The impaired synaptic plasticity and dendritic …