Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Intensive research over the past 2 decades has implicated ceramide in the regulation of
several cell responses. However, emerging evidence points to dramatic complexities in …

Since our last comprehensive review on multi‐dimensional mass spectrometry‐based
shotgun lipidomics (Mass Spectrom. Rev. 24 (2005), 367), many new developments in the …

Lipids tailor membrane identities and function as molecular hubs in all cellular processes.
However, the ways in which lipids modulate protein function and structure are poorly …

Sterols and sphingolipids are considered mainly eukaryotic lipids even though both are
present in some prokaryotes, with sphingolipids being more widespread than sterols. Both …

A First Course in Systems Biology is an introduction for advanced undergraduate and
graduate students to the growing field of systems biology. Its main focus is the development …

Yeast cells are equipped with different nutrient signaling pathways that enable them to
sense the availability of various nutrients and adjust metabolism and growth accordingly …

Diseases including cancer, type 2 diabetes, cardiovascular and immune dysfunction and
neurodegeneration become more prevalent as we age, and combined with the increase in …

The concept of ageing is one that has intrigued mankind since the beginning of time and is
now more important than ever as the incidence of age-related disorders is increasing in our …

Long‐chain bases (LCBs) are pleiotropic sphingolipidic signals in eukaryotes. We
investigated the source and function of phytosphingosine‐1‐phosphate (PHS‐P), a phospho …