Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Lactic acid bacteria (LAB) are important starter, commensal, or pathogenic microorganisms.
The stress physiology of LAB has been studied in depth for over 2 decades, fueled mostly by …

There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …

Lactobacilli have been crucial for the production of fermented products for centuries. They
are also members of the mutualistic microbiota present in the human gastrointestinal and …

The Bacillus subtilis extracytoplasmic function (ECF) σ factor σM is inducible by, and confers
resistance to, several cell envelope‐acting antibiotics. Here, we demonstrate that σM is …

Autoproteolysis has been discovered to play key roles in various biological processes, but
functional autoproteolysis has been rarely reported for transmembrane signaling in …

Members of the AAA+ protein superfamily contribute to many diverse aspects of protein
homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic …

Copper is a ubiquitous element in the environment as well as living organisms, with its redox
capabilities and complexation potential making it indispensable for many cellular functions …

The worldwide spread of antibiotic-resistant bacteria has lent urgency to the search for
antibiotics with new modes of action that are devoid of preexisting cross-resistances. We …

In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates
the response to various stresses. Mycobacteria, including Mycobacterium tuberculosis (Mtb) …