Sydney Ringer would be overwhelmed today by the implications of his simple experiment
performed over 120 years ago showing that the heart would not beat in the absence of …

Background The burden of cancer in heart failure with reduced ejection fraction is
apparently growing. Randomized controlled trials (RCTs) may help understanding this …

Background Despite therapy with diuretics, ACE inhibitors and digoxin morbidity and
mortality in heart failure remain high and might respond favorably to an additional …

Background Approximately half of people with heart failure have chronic kidney disease
(CKD). Pharmacological interventions for heart failure in people with CKD have the potential …

Background: Several reports have questioned the lack of safety data on calcium antagonists
as a drug class. Because this drug class is heterogeneous, unique features of certain …

Congestive heart failure (CHF) is a chronic disorder characterised by fatigue, shortness of
breath and congestion. Treatment is designed to relieve symptoms, halt or delay …

Calcium antagonists (CAs) are widely used in the management of hypertension and chronic
stable angina pectoris. Currently available CAs fall into three distinct structural classes—the …

The various classes of medications employed in the treatment of heart failure are reviewed
as well as the clinical trials shaping heart failure therapeutics. Appropriate staging of …

Current and novel pharmacologic approaches in advanced heart failure - ScienceDirect Skip
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BACKGROUND:: The echocardiographic substudy of the Vasodilator-Heart Failure Trial III
(V-HeFT III) aimed to determine if felodipine treatment in patients with heart failure who were …