Background Low back pain is the leading cause of years lived with disability globally, but
most interventions have only short-lasting, small to moderate effects. Cognitive functional …

Importance Opioid use for chronic nonmalignant pain can be harmful. Objective To test
whether a multicomponent, group-based, self-management intervention reduced opioid use …

Objective To determine whether primary trabeculectomy or primary medical treatment
produces better outcomes in term of quality of life, clinical effectiveness, and safety in …

Background The TANDEM multicentre, pragmatic, randomised controlled trial evaluated
whether a tailored psychological intervention based on a cognitive behavioural approach for …

Background People with multiple and persistent physical symptoms have impaired quality of
life and poor experiences of health care. We aimed to evaluate the effectiveness of a …

Children with low performance in early numeracy are at risk of facing learning difficulties in
mathematics, but few trials have examined how this can be ameliorated. A total of 120 first …

Background Group interventions are interventions delivered to groups of people rather than
to individuals and are used in healthcare for mental health recovery, behaviour change …

Background/aims Socioeconomic status (SES) is associated with late disease presentation
and poorer outcomes. We evaluate the effect of SES on treatment outcomes and report the …

Partially clustered designs are widely used in psychological research, especially in
randomized controlled trials that examine the effectiveness of prevention or intervention …

Background People with chronic obstructive pulmonary disease (COPD) are at increased
risk of depression and anxiety, which greatly reduces their quality of life and is associated …