Acute kidney injury (AKI) is a major burden on health systems and may arise from multiple
initiating insults, including ischaemia‐reperfusion injury, cardiovascular surgery …

Acute kidney injury (AKI) is a major renal disease associated with high mortality rate and
increasing prevalence. Decades of research have suggested numerous chemical and …

Nephrotoxicity is a major adverse effect of the widely used anticancer drug cisplatin.
Oxidative stress, inflammation and apoptosis are implicated in the pathophysiology of …

Renal ischemia/reperfusion (IR) injury is characterized by an unexpected impairment of
blood flow to the kidney. Azilsartan is an angiotensin receptor blocker that is approved for …

AIM: Cardiac arrest (CA) in humans causes warm renal ischemia-reperfusion injury, similar
to animal models of ischemic acute kidney injury (AKI). We aimed to investigate the …

We have reviewed the effects of angiotensin II type 1 receptor antagonists (ARBs) in various
animal models of hypertension, atherosclerosis, cardiac function, hypertrophy and fibrosis …

Nephrotoxicity is a rapid deterioration of kidney function due to exposure to nephrotoxic
drugs as gentamicin. Gentamicin increases the generation of reactive oxygen species (ROS) …

Background. Ischemia/reperfusion triggers acute kidney injury (AKI), mainly via aggravating
hypoxia, oxidative stress, inflammation and renin–angiotensin system (RAS) activation. We …

Renal ischemia is the most common cause of acute kidney injury (AKI) still associated with
high mortality rates of about 50% in the intensive care unit. Postischemic AKI is …

The main objective of this study was to determine if the telmisartan-ameliorative effects of
metabolic syndrome (MetS)-evoked nephropathy are attributed to the Hippo pathway. A …