Juvenile idiopathic arthritis is a heterogeneous group of diseases characterised by arthritis
of unknown origin with onset before age of 16 years. Pivotal studies in the past 5 years have …

Periodontitis is a chronic inflammatory condition of the periodontium involving interactions
between bacterial products, numerous cell populations and inflammatory mediators. It is …

The relevance of regulatory B cells in the maintenance of tolerance in healthy individuals or
in patients with immune disorders remains understudied. In healthy individuals, CD19+ …

Trace elements produce double-edged effects on the lives of animals and particularly of
humans. On one hand, these elements represent potentially toxic agents; on the other hand …

Summary Interleukin‐23 (IL‐23) is a member of the IL‐12 family of cytokines with pro‐
inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 …

Regulatory T-cells (TREG) are diverse populations of lymphocytes that regulate the adaptive
immune response in higher vertebrates. TREG delete autoreactive T-cells, induce tolerance …

Rheumatoid arthritis is associated with the development of autoantibodies to citrullinated
self-proteins. Citrullinated synovial proteins, which are generated via the actions of the …

Aging is associated with multiple changes in the proliferative and functional abilities of the
immune system which are not related to any pathology but consequences in …

Abstract The imbalance of Th17/Treg cell populations has been suggested to be involved in
the regulation of rheumatoid arthritis (RA) pathogenesis; however, the mechanism behind …

SSc is an autoimmune disease characterized by inflammation and extracellular matrix
deposition that ultimately leads to loss of organ function. T cells appear to play a prominent …