A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

Neural circuit function can be drastically affected by variations in the number of cells that are
produced during development or by a reduction in adult cell number owing to disease. For …

The basic helix-loop-helix transcription factors Ascl1/Mash1, Hes1, and Olig2 regulate fate
choice of neurons, astrocytes, and oligodendrocytes, respectively. These same factors are …

Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a
functional relationship between the stem cells and blood vessel component cells. We show …

Transgenic mice expressing a stabilized β-catenin in neural precursors develop enlarged
brains with increased cerebral cortical surface area and folds resembling sulci and gyri of …

The large number of candidate genes made available by comprehensive genome analysis
requires that relatively rapid techniques for the study of function be developed. Here, we …

Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease.
Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin …

The discovery that the adult mammalian brain creates new neurons from pools of stemlike
cells was a breakthrough in neuroscience. Interestingly, this particular new form of structural …

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are
poorly understood. We determined global gene expression profiles for mouse and human …

Neural stem cells (NSCs) in the adult hippocampus divide infrequently, and the molecules
that modulate their quiescence are largely unknown. Here, we show that bone …