Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a
dismal prognosis. The current mainstay of treatment involves maximally safe surgical …

The metabolic reprogramming of glioblastoma (GBM) poses a tremendous obstacle to
effective immunotherapy due to its impact on the immunosuppressive microenvironment. In …

Despite a deeper molecular understanding, human glioblastoma remains one of the most
treatment refractory and fatal cancers. It is known that the presence of macrophages and …

MRI-based medical image analysis for brain tumor studies is gaining attention in recent
times due to an increased need for efficient and objective evaluation of large amounts of …

Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …

Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Background Intraoperative MRI is increasingly used in neurosurgery, although there is little
evidence for its use. We aimed to assess efficacy of intraoperative MRI guidance on extent of …

Cell-based drug delivery systems have shown promising capability for tumor-targeted
therapy owing to the intrinsic tumor-homing and drug-carrying property of some living cells …

The alkylating agent temozolomide (TMZ) together with maximal safe bulk resection and
focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly …