Chronic pain can occur after peripheral nerve injury, infection, or inflammation. Under such
neuropathic pain conditions, sensory processing in the affected body region becomes …

Advanced peripheral diabetic neuropathy (PDN) is associated with elevated vibration and
thermal perception thresholds that progress to sensory loss and degeneration of all fiber …

Study Design. Immunohistochemical study of tumor necrosis factor α expression in autopsy
and surgical specimens of human lumbar intervertebral discs. Objectives. To investigate the …

Acid-sensing ionic channels (ASICs) are almost ubiquitous in the mammalian nervous
system, both at the periphery and in the brain. Strong evidence for the physiological function …

Neuroinflammation is a proinflammatory cytokine-mediated process that can be provoked by
systemic tissue injury but it is most often associated with direct injury to the nervous system …

It has been 50years since Gross and Lapiere discovered collagenolytic activity during
tadpole tail metamorphosis, which was later on revealed as MMP-1, the founding member of …

The 'vanishing bone'or inherited osteolysis/arthritis syndromes represent a heterogeneous
group of skeletal disorders characterized by mineralization defects of affected bones and …

As a metalloproteinase specialized in releasing membrane-tethered proteins, A Disintegrin
and A Metalloproteinase 17 (ADAM17), also known as Tumor necrosis factor-α Converting …

Peripheral nerve injuries, particularly in the upper limb, may have devastating
consequences. The outcome of injury is determined by the amount of cellular damage, and …

Following peripheral nerve injury, remnant Schwann cells adopt a migratory phenotype and
remodel the extracellular matrix allowing axonal regrowth. Although much evidence has …