BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

Background Recent research on the implications of gut microbiota on brain functions has
helped to gather important information on the relationship between them. Pathogenesis of …

Several metabolic alterations accumulate over time along with a reduction in biological
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …

Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

Huntington's disease (HD), a neurodegenerative disease, normally starts in the prime of
adult life, followed by a gradual occurrence of characteristic psychiatric disturbances and …

Animal models are used to better understand the various mechanisms involved in the
pathogenesis of diseases and explore potential pathways that will aid in discovering …

Spermidine is a naturally occurring polyamine compound that has many biological functions,
such as inducing autophagy and anti-inflammatory and anti-aging effects. Spermidine can …

Intracerebral hemorrhage (ICH) may be caused by trauma, aneurysm and arteriovenous
malformation, as can any bleeding within the intracranial vault, including brain parenchyma …

Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …

Parkinson's disease is a leading hypokinetic disorder characterized by selective loss of
dopaminergic neurons in substantia nigra pars compacta (SNpc) region of mid-brain …