Creating an artificial cell from the bottom up is a long‐standing challenge and, while
significant progress has been made, the full realization of this goal remains elusive …

Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy
cells remains one of the most ambitious objectives in pharmacology. Nanomedicine, which …

Microfluidic production of giant lipid vesicles presents a paradigm-shift in the development of
artificial cells. While production is high-throughput and the lipid vesicles are mono-disperse …

Bottom-up and top-down approaches to synthetic biology each employ distinct
methodologies with the common aim to harness living systems. Here, we realize a strategic …

Giant unilamellar vesicles (GUVs) are often used to mimic biological membranes in
reconstitution experiments. They are also widely used in research on synthetic cells, as they …

Cell-sized vesicles like giant unilamellar vesicles (GUVs) are established as a promising
biomimetic model for studying cellular phenomena in isolation. However, the presence of …

Disruption of cell membranes is a fundamental host defense response found in virtually all
forms of life. The molecular mechanisms vary but generally lead to energetically favored …

Lipid vesicles (liposomes) are a unique and fascinating type of polymolecular aggregates,
obtained from bilayer-forming amphiphiles—or mixtures of amphiphiles—in an aqueous …

Host defense or antimicrobial peptides hold promise for providing new pipelines of effective
antimicrobial agents. Their activity quantified against model phospholipid membranes is …

The biophysical properties of lipid vesicles are important for their stability and integrity, key
parameters that control the performance when these vesicles are used for drug delivery. The …