PDZ domains are abundant protein interaction modules that often recognize short amino
acid motifs at the C-termini of target proteins. They regulate multiple biological processes …

Therapies for stroke have remained elusive in the past despite the great relevance of this
pathology. However, recent results have provided strong evidence that postsynaptic density …

Inhibition of the ternary protein complex of the synaptic scaffolding protein postsynaptic
density protein-95 (PSD-95), neuronal nitric oxide synthase (nNOS), and the N-methyl-d …

Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled
receptors, has directly enabled the discovery of most drugs developed to modulate receptor …

Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …

Inhibiting the protein–protein interaction (PPI) between the transcription factor Nrf2 and its
repressor protein Keap1 has emerged as a promising strategy to target oxidative stress in …

Chemical denaturant titrations can be used to accurately determine protein stability.
However, data acquisition is typically labour intensive, has low throughput and is difficult to …

Abstract Post-synaptic density-95, disks-large and zonula occludens-1 (PDZ) domains are
small globular protein–protein interaction domains widely conserved from yeast to humans …

Proteins containing PSD-95/Discs-large/ZO-1 homology (PDZ) domains play key roles in the
assembly and regulation of cellular signaling pathways and represent putative targets for …

The protein− protein interaction between the NMDA receptor and its intracellular scaffolding
protein, PSD-95, is a potential target for treating ischemic brain diseases, neuropathic pain …