Why do tethered-bilayer lipid membranes suit for functional membrane protein reincorporation?

AP Girard-Egrot, O Maniti - Applied Sciences, 2021 - mdpi.com
Membrane proteins (MPs) are essential for cellular functions. Understanding the functions of
MPs is crucial as they constitute an important class of drug targets. However, MPs are a …

The adenylate cyclase toxin RTX domain follows a series templated folding mechanism with implications for toxin activity

G Chen, H Wang, L Bumba, J Masin, P Sebo… - Journal of Biological …, 2023 - ASBMB
Folding of the RTX domain (Repeats-in-toxin) of the bacterial adenylate cyclase toxin-
hemolysin (CyaA) is critical to its toxin activities and the virulence of the whooping cough …

Membrane Activity and Channel Formation of the Adenylate Cyclase Toxin (CyaA) of Bordetella pertussis in Lipid Bilayer Membranes

O Knapp, R Benz - Toxins, 2020 - mdpi.com
The Gram-negative bacterium Bordetella pertussis is the cause of whooping cough. One of
its pathogenicity factors is the adenylate cyclase toxin (CyaA) secreted by a Type I export …

A High‐Affinity Calmodulin‐Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells

A Voegele, M Sadi, DP O'Brien, P Gehan… - Advanced …, 2021 - Wiley Online Library
The molecular mechanisms and forces involved in the translocation of bacterial toxins into
host cells are still a matter of intense research. The adenylate cyclase (CyaA) toxin from …

Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin

CA Espinosa-Vinals, J Masin, J Holubova… - Journal of Biological …, 2021 - ASBMB
The whooping cough agent Bordetella pertussis secretes an adenylate cyclase toxin (CyaA)
that through its large carboxy-proximal Repeat-in-ToXin (RTX) domain binds the …

A Periplasmic Lanthanide Mediator, Lanmodulin, in Methylobacterium aquaticum Strain 22A

Y Fujitani, T Shibata, A Tani - Frontiers in Microbiology, 2022 - frontiersin.org
Methylobacterium and Methylorubrum species oxidize methanol via pyrroloquinoline
quinone-methanol dehydrogenases (MDHs). MDHs can be classified into two major groups …

Isolation and genomic characterization of a pathogenic Providencia rettgeri strain G0519 in turtle Trachemys scripta

M Ye, X Hu, A Lü, J Sun, C Chen - Antonie Van Leeuwenhoek, 2020 - Springer
Providencia rettgeri infection has occurred occasionally in aquaculture, but is rare in turtles.
Here, a pathogenic P. rettgeri strain G0519 was isolated from a diseased slider turtle …

CyaA translocation across eukaryotic cell membranes

A Abettan, MH Nguyen, D Ladant… - Frontiers in Molecular …, 2024 - frontiersin.org
The adenylate cyclase (CyaA) toxin is a major virulence factor produced by Bordetella
pertussis, the causative agent of whooping cough and is involved in the early stages of …

Highlights of the 12th International Bordetella Symposium

C Locht, NH Carbonetti, JD Cherry… - Clinical Infectious …, 2020 - academic.oup.com
To commemorate the 100th anniversary of the Nobel prize being awarded to Jules Bordet,
the discoverer of Bordetella pertussis, the 12th International Bordetella Symposium was held …

Development and characterisation of a novel vaccine for Bordetella pertussis (whooping cough)

M Kristof - 2023 - ora.ox.ac.uk
Bordetella pertussis is the causative agent of pertussis (whooping cough) which is a
respiratory infection, particularly dangerous for babies and young infants. Protection against …