Osteoimmunology: interactions of the bone and immune system
J Lorenzo, M Horowitz, Y Choi - Endocrine reviews, 2008 - academic.oup.com
Bone and the immune system are both complex tissues that respectively regulate the
skeleton and the body's response to invading pathogens. It has now become clear that these …
skeleton and the body's response to invading pathogens. It has now become clear that these …
The zinc finger-containing transcription factors GATA-4,-5, and-6: ubiquitously expressed regulators of tissue-specific gene expression
JD Molkentin - Journal of Biological Chemistry, 2000 - ASBMB
Six GATA transcription factors have been identified in vertebrates, each of which contains a
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys …
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys …
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Re-expression of the paralogous γ-globin genes (HBG1/2) could be a universal strategy to
ameliorate the severe β-globin disorders sickle cell disease (SCD) and β-thalassemia by …
ameliorate the severe β-globin disorders sickle cell disease (SCD) and β-thalassemia by …
Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
Tissue-specific gene expression requires coordinated control of gene-proximal and-distal
cis-regulatory elements (CREs), yet functional analysis of gene-distal CREs such as …
cis-regulatory elements (CREs), yet functional analysis of gene-distal CREs such as …
[HTML][HTML] Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor
Chromatin loops juxtapose distal enhancers with active promoters, but their molecular
architecture and relationship with transcription remain unclear. In erythroid cells, the locus …
architecture and relationship with transcription remain unclear. In erythroid cells, the locus …
An expansive human regulatory lexicon encoded in transcription factor footprints
Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage
by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting …
by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting …
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
F Shalaby, J Rossant, TP Yamaguchi, M Gertsenstein… - Nature, 1995 - nature.com
THE receptor tyrosine kinase Flk-1 (ref. 1) is believed to play a pivotal role in endothelial
development. Expression of the Flk-1 receptor is restricted to endothelial cells and their …
development. Expression of the Flk-1 receptor is restricted to endothelial cells and their …
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus …
P Moi, K Chan, I Asunis, A Cao… - Proceedings of the …, 1994 - National Acad Sciences
Hypersensitive site 2 located in the beta-globin locus control region confers high levels of
expression to the genes of the beta-globin cluster. A tandem repeat of the consensus …
expression to the genes of the beta-globin cluster. A tandem repeat of the consensus …
[HTML][HTML] Circuitry and dynamics of human transcription factor regulatory networks
The combinatorial cross-regulation of hundreds of sequence-specific transcription factors
(TFs) defines a regulatory network that underlies cellular identity and function. Here we use …
(TFs) defines a regulatory network that underlies cellular identity and function. Here we use …
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
THE vascular endothelial growth factor (VEGF) and its high-affinity binding receptors, the
tyrosine kinases Flt-1 and Flk-1, are thought to be important for the development of …
tyrosine kinases Flt-1 and Flk-1, are thought to be important for the development of …