Elastin structure, synthesis, regulatory mechanism and relationship with cardiovascular diseases

K Wang, X Meng, Z Guo - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
As the primary component of elastic fibers, elastin plays an important role in maintaining the
elasticity and tensile ability of cardiovascular, pulmonary and many other tissues and …

Peripheral blood mononuclear cell secretome for tissue repair

L Beer, M Mildner, M Gyöngyösi, HJ Ankersmit - Apoptosis, 2016 - Springer
For almost two decades, cell-based therapies have been tested in modern regenerative
medicine to either replace or regenerate human cells, tissues, or organs and restore normal …

[HTML][HTML] Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution

L Bao, G Dou, R Tian, Y Lv, F Ding, S Liu, R Zhao… - Bioactive materials, 2022 - Elsevier
Inflammatory response plays a critical role in myocardial infarction (MI) repair. The
neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation …

Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction

V Dayan, G Yannarelli, F Billia, P Filomeno… - Basic research in …, 2011 - Springer
Given the established anti-inflammatory properties of mesenchymal stromal cells (MSCs),
we investigated their effect on inflammatory cell infiltration of ischemic cardiac tissue and …

Analysis of the secretome of apoptotic peripheral blood mononuclear cells: impact of released proteins and exosomes for tissue regeneration

L Beer, M Zimmermann, A Mitterbauer, A Ellinger… - Scientific reports, 2015 - nature.com
We previously showed that, when peripheral blood mononuclear cells (PBMCs) were
stressed with ionizing radiation, they released paracrine factors that showed regenerative …

[HTML][HTML] Cell secretome based drug substances in regenerative medicine: when regulatory affairs meet basic science

L Beer, M Mildner, HJ Ankersmit - Annals of translational medicine, 2017 - ncbi.nlm.nih.gov
“Regenerative medicine” or “tissue regeneration” had become to an inspired term recently
since it has been realized in the last decade that many organs such as the skin display …

Apoptotic neutrophil-mediated inflammatory microenvironment regulation for the treatment of ARDS

X Liu, Q Qiao, X Li, X Ou, K Cui, B Niu, C Yang, L Kong… - Nano Today, 2023 - Elsevier
Acute respiratory distress syndrome (ARDS) is a critical respiratory disease characterized by
uncontrolled acute lung inflammation with high mortality. At present, effective therapeutic …

Regenerative cardiovascular therapies: stem cells and beyond

B Wernly, M Mirna, R Rezar, C Prodinger… - International journal of …, 2019 - mdpi.com
Although reperfusion therapy has improved outcomes, acute myocardial infarction (AMI) is
still associated with both significant mortality and morbidity. Once irreversible myocardial cell …

Cell therapy for human ischemic heart diseases: critical review and summary of the clinical experiences

N Pavo, S Charwat, N Nyolczas, A Jakab… - Journal of molecular and …, 2014 - Elsevier
A decade ago, stem or progenitor cells held the promise of tissue regeneration in human
myocardium, with the expectation that these therapies could rescue ischemic myocyte …

Stem cells and regenerative medicine—future perspectives

KR Brunt, RD Weisel, RK Li - Canadian journal of physiology …, 2012 - cdnsciencepub.com
Stem cell research has expanded at an exponential rate, but its therapeutic applications
have progressed much more slowly. Currently, the research focuses on understanding …