The extracellular matrix (ECM) surrounds cells in the brain, providing structural and
functional support. Emerging studies demonstrate that the ECM plays important roles during …

Abstract Spinocerebellar ataxia type 1 (SCA1) is one of nine polyglutamine (polyQ) diseases
and is characterized as an adult late-onset, progressive, dominantly inherited genetic …

Summary Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative
disease in that it is caused by a mutation in a broadly expressed protein, ATXN1; however …

Summary Spinocerebellar ataxia type 1 (SCA1) is a dominant trinucleotide repeat
neurodegenerative disease characterized by motor dysfunction, cognitive impairment, and …

Abstract Spinocerebellar ataxia type 2 (SCA2) is a polyglutamine disorder caused by a
pathological expansion of CAG repeats in ATXN2 gene. SCA2 is accompanied by cerebellar …

Spinocerebellar ataxias (SCAs) represent a large group of hereditary degenerative diseases
of the nervous system, in particular the cerebellum, and other systems that manifest with a …

Fear and anxiety have proven to be essential during the evolutionary process. However, the
mechanisms involved in recognizing and categorizing threat probability (ie low to high) to …

Bergmann glia (BG) are highly specialized radial astrocytes of the cerebellar cortex, which
play a key role in the uptake of synaptic glutamate via the excitatory amino acid transporter …

Abstract Spinocerebellar ataxia type 2 (SCA2) is a hereditary disorder, caused by an
expansion of polyglutamine in the ataxin-2 protein. Although the mutant protein is expressed …

Abstract Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused
by abnormal expansion of glutamine-encoding CAG repeats in the Ataxin-1 (ATXN1) gene …