Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Drug Resistance: A Retrospective Observational Study in Eastern China

M Zhang, Y Lu, Y Zhu, K Wu, S Chen, L Zhou, F Wang… - Antibiotics, 2023 - mdpi.com
Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis
(MTB). Whole-genome sequencing (WGS) holds great promise as an advanced technology …

Exploring Diagnostic Methods for Drug-Resistant Tuberculosis: A Comprehensive Overview

A Sanchini, A Lanni, F Giannoni, A Mustazzolu - Tuberculosis, 2024 - Elsevier
Despite available global efforts and funding, Tuberculosis (TB) continues to affect a
considerable number of patients worldwide. Policy makers and stakeholders set clear goals …

Multidrug-resistant tuberculosis

DA Wulandari, YW Hartati, AU Ibrahim, DAE Pitaloka - Clinica Chimica …, 2024 - Elsevier
One of predominant contributors to global mortality is tuberculosis (TB), an infection caused
by Mycobacterium tuberculosis (MTB). Inappropriate and ineffectual treatment can lead to …

Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures

X Wu, G Tan, W Sha, H Liu, J Yang, Y Guo… - Microbiology …, 2022 - Am Soc Microbiol
Our objective was to evaluate the performance of whole-genome sequencing (WGS) from
early positive liquid cultures for predicting Mycobacterium tuberculosis complex (MTBC) …

Analysis of Drug-Resistance Characteristics and Genetic Diversity of Multidrug-Resistant Tuberculosis Based on Whole-Genome Sequencing on the Hainan Island …

J Wang, C Yu, Y Xu, Z Chen, W Qiu… - Infection and Drug …, 2023 - Taylor & Francis
Purpose Given the high burden of Tuberculosis (TB) in China, the prevalence of multidrug-
resistant tuberculosis (MDR-TB) is significant. Whole-genome sequencing (WGS) of …

Drug-Resistant Pulmonary Tuberculosis

O Putri, MA Salim, A Gunawan, D Devin… - Indonesian Journal of …, 2023 - journal.i3l.ac.id
Tuberculosis (TB) caused by the pathogenic bacteria Mycobacterium tuberculosis (MTb) still
remains a highly prevalent disease, particularly in low and middle-income countries. Due to …

Genome sequencing analysis of the pncA, rpsA and panD genes responsible for pyrazinamide resistance of Mycobacterium tuberculosis from Indonesian isolates

A Rukmana, M Nurfadillah, C Gozali… - Tropical Medicine & …, 2024 - Wiley Online Library
Background Developing the most suitable treatment against tuberculosis based on
resistance profiles is imperative to effectively cure tuberculosis patients. Whole‐genome …

Mutation Detection of Multidrug-Resistant Tuberculosis by RT-PCR Method as the Diagnostic Tool of MDR-TB

S Pambudi - Jurnal Bioteknologi dan Biosains Indonesia, 2023 - ejournal.brin.go.id
Eight percent of tuberculosis (TB) cases worldwide are resistant to rifampicin, with mutations
occurring in the rpoB and katG genes. It is necessary to develop a specific multidrug …

The COMBAT-TB Workbench: Making Powerful Mycobacterium tuberculosis Bioinformatics Accessible

P van Heusden, Z Mashologu, T Lose, R Warren… - Msphere, 2022 - Am Soc Microbiol
Whole-genome sequencing (WGS) is a powerful method for detecting drug resistance,
genetic diversity, and transmission dynamics of Mycobacterium tuberculosis. Implementation …

Phylogenetic lineages of tuberculosis isolates and their association with patient demographics in Tanzania

BK Mutayoba, M Hoelscher, N Heinrich, ML Joloba… - BMC genomics, 2022 - Springer
Background Mycobacterium tuberculosis presents several lineages each with distinct
characteristics of evolutionary status, transmissibility, drug resistance, host interaction …