The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …

Accumulating evidence has indicated that sirtuins are key components of diverse
physiological processes, including metabolism and aging. Sirtuins confer protection from a …

Podocytes are known to play a determining role in the progression of proteinuric kidney
disease. N6-methyladenosine (m6A), as the most abundant chemical modification in …

The coenzyme nicotinamide adenine dinucleotide (NAD+) has key roles in the regulation of
redox status and energy metabolism. NAD+ depletion is emerging as a major contributor to …

Diabetic nephropathy (DN) is a research priority for scientists around the world because of
its high prevalence and poor prognosis. Although several mechanisms have been shown to …

Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …

Fenofibrate (FF), as a peroxisome-proliferator-activated receptor α (PPARα) agonist, has
been used clinically for decades to lower lipid levels. In the present study, we examined …

Background Aging is associated with impaired renal function and structural alterations.
Oxidative stress plays a vital role in renal senescence and damage. Sirtuin 1 (SIRT1) is …

Background and Purpose Catalpol, a water‐soluble active ingredient isolated from
Rehmannia glutinosa, exhibits multiple pharmacological activities. However, the mechanism …

Abnormal bone metabolism is an integral part of the chronic kidney disease-mineral bone
disorder (CKD-MBD). For several reasons, the difficult bone compartment was neglected for …