Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Both hereditary and sporadic breast cancer are suggested to develop from a stem cell
subcomponent retaining most key stem cell properties but with dysregulation of self-renewal …

N 6-methyladenosine (m6A) modification of mRNA plays a role in regulating embryonic stem
cell pluripotency. However, the physiological signals that determine the balance between …

The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer
metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may …

Abstract Cancer Stem Cells (CSCs) are now considered the primary" seeds" for the onset,
development, metastasis, and recurrence of tumors. Despite therapeutic breakthroughs …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

The homeobox domain transcription factor NANOG, a key regulator of embryonic
development and cellular reprogramming, has been reported to be broadly expressed in …

Simple Summary When tumors become resistant to chemotherapeutics, alternative
treatment strategies must be explored. Gene targeting provides a personalized and …

Abstract The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous
tissues compared to normal tissues and has regulatory roles in cell proliferation, cell …

Cancer progression is a multifaceted process that entails several stages and demands the
persistent expression or activation of transcription factors (TFs) to facilitate growth and …