Organoids

Z Zhao, X Chen, AM Dowbaj, A Sljukic… - Nature Reviews …, 2022 - nature.com
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

[HTML][HTML] Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

A Marsee, FJM Roos, MMA Verstegen, F Roos… - Cell stem cell, 2021 - cell.com
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

T Brevini, M Maes, GJ Webb, BV John, CD Fuchs… - Nature, 2023 - nature.com
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …

Transplantation of a human liver following 3 days of ex situ normothermic preservation

PA Clavien, P Dutkowski, M Mueller… - Nature …, 2022 - nature.com
Current organ preservation methods provide a narrow window (usually< 12 hours) to
assess, transport and implant donor grafts for human transplantation. Here we report the …

Modularized microrobot with lock-and-detachable modules for targeted cell delivery in bile duct

L Su, D Jin, Y Wang, Q Wang, C Pan, S Jiang… - Science …, 2023 - science.org
The magnetic microrobots promise benefits in minimally invasive cell-based therapy.
However, they generally suffer from an inevitable compromise between their magnetic …

Machine perfusion in liver transplantation

RX Sousa Da Silva, A Weber, P Dutkowski… - …, 2022 - Wiley Online Library
Although liver transplantation is a true success story, many patients still die awaiting an
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …

Modelling metabolic diseases and drug response using stem cells and organoids

W Hu, MA Lazar - Nature Reviews Endocrinology, 2022 - nature.com
Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

[HTML][HTML] Recent advances in defined hydrogels in organoid research

Z Gan, X Qin, H Liu, J Liu, J Qin - Bioactive Materials, 2023 - Elsevier
Organoids are in vitro model systems that mimic the complexity of organs with multicellular
structures and functions, which provide great potential for biomedical and tissue …

[HTML][HTML] Living materials for regenerative medicine

Y Yu, Q Wang, C Wang, L Shang - Engineered Regeneration, 2021 - Elsevier
Regenerative medicine has been attracting tremendous attention during the past few
decades because it is promising in overcoming the limitations of donor shortage and …

Biliary Atresia–emerging diagnostic and therapy opportunities

U Lendahl, VCH Lui, PHY Chung, PKH Tam - EBioMedicine, 2021 - thelancet.com
Biliary Atresia is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. In
this review, we describe recent progress in the understanding of liver development with a …