The main advances in immunology have been forged or underpinned by animal
experiments. However, animal research now focuses excessively on one laboratory species …

Recent advances in high-throughput molecular testing have made it possible to diagnose
most genetic disorders relatively early in gestation with minimal risk to the fetus. These …

In this study we investigate the efficacy of lentiviral vectors of different pseudotypes for gene
transfer to tissues of the preimmune fetus. BALB/c fetuses at 14–15 days' gestation received …

We are living in a golden age of medicine in which the availability of prenatal diagnosis, fetal
therapy, and gene therapy/editing make it theoretically possible to repair almost any defect …

Advances in prenatal diagnosis have led to the prenatal management and treatment of a
variety of congenital diseases. Although surgical treatment has been successfully applied to …

Gene therapy uses the intracellular delivery of genetic material for the treatment of disease.
A wide range of diseases–including cancer, vascular and neurodegenerative disorders and …

The successful transduction of hematopoietic stem cells and long-term (28 months)
transgene expression within the hematopoietic system following the direct injection of high …

This report is the third in a series of studies that aimed to compile physiological parameters
related to develop physiologically based pharmacokinetic (PBPK) models for drugs and …

Over the past few years, considerable progress in prenatal diagnosis and surgery combined
with improvements in vector design vindicate a reappraisal of the feasibility of in utero gene …

Many life-threatening conditions that can be diagnosed early in gestation may be treatable
in utero using gene therapy. In order to determine in utero gene transfer efficiency and …