Crosstalk between Wnt/β-Catenin and NF-κB signaling pathway during inflammation
B Ma, MO Hottiger - Frontiers in immunology, 2016 - frontiersin.org
Besides its important role in embryonic development and homeostatic self-renewal in adult
tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory …
tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory …
Crosstalk between peroxisome proliferator-activated receptor gamma and the canonical WNT/β-catenin pathway in chronic inflammation and oxidative stress during …
A Vallée, Y Lecarpentier - Frontiers in immunology, 2018 - frontiersin.org
Inflammation and oxidative stress are common and co-substantial pathological processes
accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β …
accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β …
LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer
Y Wang, JH Lu, QN Wu, Y Jin, DS Wang, YX Chen… - Molecular cancer, 2019 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) play nonnegligible roles in the
epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that …
epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that …
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Abstract N 6-methyladenosine (m6A) is the most prevalent modification in eukaryotic
messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain …
messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain …
IGF2BP1 promotes SRF-dependent transcription in cancer in am6A- and miRNA-dependent manner
The oncofetal mRNA-binding protein IGF2BP1 and the transcriptional regulator SRF
modulate gene expression in cancer. In cancer cells, we demonstrate that IGF2BP1 …
modulate gene expression in cancer. In cancer cells, we demonstrate that IGF2BP1 …
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
Following the discovery of BRD4 as a non-oncogene addiction target in acute myeloid
leukaemia (AML),, bromodomain and extra terminal protein (BET) inhibitors are being …
leukaemia (AML),, bromodomain and extra terminal protein (BET) inhibitors are being …
[HTML][HTML] The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer
D Ramesh-Kumar, S Guil - Seminars in Cancer Biology, 2022 - Elsevier
RNA binding proteins that act at the post-transcriptional level display a richness of
mechanisms to modulate the transcriptional output and respond to changing cellular …
mechanisms to modulate the transcriptional output and respond to changing cellular …
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
JL Bell, K Wächter, B Mühleck, N Pazaitis… - Cellular and molecular …, 2013 - Springer
The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2,
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …
Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
[HTML][HTML] Widespread shortening of 3′ UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to
tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed …
tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed …