Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

Inflammation is emerging as a critical mechanism underlying neurological disorders of
various etiologies, yet its role in altering brain function as a consequence of neuroinfectious …

Changes in gene expression that occur across the central nervous system (CNS) during
neurological diseases do not address the heterogeneity of cell types from one CNS region to …

Meningeal lymphatics near the cribriform plate undergo lymphangiogenesis during
neuroinflammation to drain excess fluid. Here, we hypothesized that lymphangiogenic …

Astrocytes are essential for the development and homeostatic maintenance of the central
nervous system (CNS). They are also critical players in the CNS injury response during …

Background After bilateral kidney ischemia/reperfusion injury (IRI), monocytes infiltrate the
kidney and differentiate into proinflammatory macrophages in response to the initial kidney …

Early-phase clinical trials evaluating CD8+ T cell–eliciting, HER2-derived peptide vaccines
administered to HER2+ breast cancer patients in the adjuvant setting suggest synergy …

Recent evidence suggests that a substantial portion of complex disease risk alleles modify
gene expression in a cell-specific manner,,,. To identify candidate causal genes and …

Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …

Neuroinflammation contributes substantially to stroke pathophysiology. Cerebral invasion of
peripheral leukocytes—particularly T cells—has been shown to be a key event promoting …