[HTML][HTML] Regulation of Bim in health and disease
The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …
under both physiological and pathophysiological conditions. Tight regulation of its …
Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review
MJ Millan - Progress in neurobiology, 2017 - Elsevier
The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …
[HTML][HTML] Cell cycle deficits in neurodegenerative disorders: uncovering molecular mechanisms to drive innovative therapeutic development
Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative
disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell …
disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell …
[HTML][HTML] Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against …
B Wang, F Peng, W Huang, J Zhou, N Zhang… - … Pharmaceutica Sinica B, 2020 - Elsevier
Simultaneous inhibition of MDM2 and CDK4 may be an effective treatment against
glioblastoma. A collection of chiral spirocyclic tetrahydronaphthalene (THN)-oxindole …
glioblastoma. A collection of chiral spirocyclic tetrahydronaphthalene (THN)-oxindole …
[HTML][HTML] Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling
Repurposing approved drugs is an emerging therapeutic development strategy for
Alzheimer's disease (AD). The CDK4/6 inhibitor abemaciclib mesylate is an FDA-approved …
Alzheimer's disease (AD). The CDK4/6 inhibitor abemaciclib mesylate is an FDA-approved …
In vitro Evaluation of the Anti-inflammatory Effects of Thymoquinone in Osteoarthritis and in silico Analysis of Inter-Related Pathways in Age-Related Degenerative …
G Kalamegam, SM Alfakeeh, AO Bahmaid… - Frontiers in cell and …, 2020 - frontiersin.org
Chronic inflammation is a common underlying factor in osteoarthritis (OA) and most age-
related degenerative diseases. As conventional therapies help only in partial alleviation of …
related degenerative diseases. As conventional therapies help only in partial alleviation of …
TIMP-1: A key cytokine released from activated astrocytes protects neurons and ameliorates cognitive behaviours in a rodent model of Alzheimer's disease
Alzheimer's disease (AD) is characterized by two pathologic species, extracellular amyloid-β
(Aβ) plaques and intracellular neurofibrillary tangles. Astrocytes that maintain normal …
(Aβ) plaques and intracellular neurofibrillary tangles. Astrocytes that maintain normal …
[HTML][HTML] Melatonin as a harmonizing factor of circadian rhythms, neuronal cell cycle and neurogenesis: additional arguments for its therapeutic use in Alzheimer's …
M Shukla, B Vincent - Current Neuropharmacology, 2023 - ncbi.nlm.nih.gov
The synthesis and release of melatonin in the brain harmonize various physiological
functions. The apparent decline in melatonin levels with advanced aging is an aperture to …
functions. The apparent decline in melatonin levels with advanced aging is an aperture to …
Tau and DNA damage in neurodegeneration
L Colnaghi, D Rondelli, M Muzi-Falconi, S Sertic - Brain Sciences, 2020 - mdpi.com
Neurodegenerative disorders are a family of incurable conditions. Among them, Alzheimer's
disease and tauopathies are the most common. Pathological features of these two disorders …
disease and tauopathies are the most common. Pathological features of these two disorders …
P38K and JNK pathways are induced by amyloid-β in astrocyte: Implication of MAPK pathways in astrogliosis in Alzheimer's disease
Astrocyte activation is one of the crucial hallmarks of Alzheimer's disease (AD) along with
amyloid-β (Aβ) plaques, neurofibrillary tangles and neuron death. Glial scar and factors …
amyloid-β (Aβ) plaques, neurofibrillary tangles and neuron death. Glial scar and factors …