Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

[HTML][HTML] Application of nanotechnology in cancer diagnosis and therapy-a mini-review

C Jin, K Wang, A Oppong-Gyebi… - International Journal of …, 2020 - ncbi.nlm.nih.gov
Cancer is a leading cause of death and poor quality of life globally. Even though several
strategies are devised to reduce deaths, reduce chronic pain and improve the quality of life …

APT‐weighted MRI: techniques, current neuro applications, and challenging issues

J Zhou, HY Heo, L Knutsson… - Journal of Magnetic …, 2019 - Wiley Online Library
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that
generates image contrast based predominantly on the amide protons in mobile cellular …

Magnetization transfer contrast and chemical exchange saturation transfer MRI. Features and analysis of the field-dependent saturation spectrum

PCM Van Zijl, WW Lam, J Xu, L Knutsson, GJ Stanisz - Neuroimage, 2018 - Elsevier
Abstract Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation
Transfer (CEST) experiments measure the transfer of magnetization from molecular protons …

A molecular imaging primer: modalities, imaging agents, and applications

ML James, SS Gambhir - Physiological reviews, 2012 - journals.physiology.org
Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …

Chemical exchange saturation transfer (CEST): what is in a name and what isn't?

PCM Van Zijl, NN Yadav - Magnetic resonance in medicine, 2011 - Wiley Online Library
Chemical exchange saturation transfer (CEST) imaging is a relatively new magnetic
resonance imaging contrast approach in which exogenous or endogenous compounds …

Magnetic resonance imaging of glutamate

K Cai, M Haris, A Singh, F Kogan, JH Greenberg… - Nature medicine, 2012 - nature.com
Glutamate, a major neurotransmitter in the brain, shows a pH-and concentration-dependent
chemical exchange saturation transfer effect (GluCEST) between its amine group and bulk …

Tracking immune cells in vivo using magnetic resonance imaging

ET Ahrens, JWM Bulte - Nature Reviews Immunology, 2013 - nature.com
The increasing complexity of in vivo imaging technologies, coupled with the development of
cell therapies, has fuelled a revolution in immune cell tracking in vivo. Powerful magnetic …

Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides

J Zhou, E Tryggestad, Z Wen, B Lal, T Zhou… - Nature medicine, 2011 - nature.com
It remains difficult to distinguish tumor recurrence from radiation necrosis after brain tumor
therapy. Here we show that these lesions can be distinguished using the amide proton …

Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7 T

CK Jones, A Huang, J Xu, RAE Edden, M Schär, J Hua… - Neuroimage, 2013 - Elsevier
Chemical exchange saturation transfer (CEST) is a magnetization transfer (MT) technique to
indirectly detect pools of exchangeable protons through the water signal. CEST MRI has …